To help you set your fantasy football lineups and to avoid starting a player who won’t be in the lineup, we’ll post fantasy-relevant updates and analysis here as NFL teams release their inactives, typically about 90 minutes before kickoff. Any rankings cited in this column come from our ESPN Fantasy staff ranks.
Refresh often for the latest information.
1 p.m. ET games
Create a new league today and start fresh from this point! Leagues drafted before the first game of the week will begin play immediately, while leagues drafted after the first game will start the following week.
Create or join a league today >>
Chris Moore, WR, BAL: Thigh — Questionable
Impact: Whoever suits up, Moore or Boykin, could have a solid day as Baltimore’s No. 3 WR …
Miles Boykin, WR, BAL: Thigh — Questionable
Impact: … with Devin Duvernay and James Proche II as backup options.
Curtis Samuel, WR, CAR: Knee — Questionable
Impact: A likely game-time call. Seth Roberts looms as his replacement.
Auden Tate, WR, CIN: Shoulder — Doubtful
Impact: A.J. Green will be able to play. The rise of Tee Higgins has made Tate somewhat fantasy irrelevant.
Baker Mayfield, QB, CLE: Chest — Questionable
Impact: Practiced Friday, so should be able to start. Case Keenum is the literal “just in case” option.
Odell Beckham Jr., WR, CLE: Illness — Questionable
Impact: Expected to play after recovering from what team is calling a non-COVID illness earlier in the week.
Jarvis Landry, WR, CLE: Ribs — Questionable
Impact: Also expected to suit up, with Rashard Higgins on deck if he can’t.
Drew Lock, QB, DEN: Shoulder — Questionable
Impact: Blake Bortles was released — a sign of confidence that Lock will play.
Melvin Gordon III, RB, DEN: Illness — OUT
Impact: Didn’t travel to New England. Phillip Lindsay to handle No. 1 RB workload.
KJ Hamler, WR, DEN: Hamstring — OUT
Impact: DaeSean Hamilton should be involved in 3-WR sets.
Noah Fant, TE, DEN: Ankle — OUT
Impact: Nick Vannett/Jake Butt to share the TE workload in Denver.
Jordan Wilkins, RB, IND: Calf — Questionable
Impact: Very little practice this week. Nyheim Hines could get a few extra touches.
Mo Alie-Cox, TE, IND: Knee — OUT
Impact: Trey Burton has potential for a good number of TE targets.
DJ Chark Jr., WR, JAX: Ankle — Questionable
Impact: Game-time call. Laviska Shenault Jr. has played very well in recent weeks.
Tyler Eifert, TE, JAX: Neck — Questionable
Impact: Missed two days of practice, leaving James O’Shaughnessy as the likely starter.
Dalvin Cook, RB, MIN: Groin — OUT
Impact: If you had Alexander Mattison as an insurance policy, now’s the time to cash in.
Julian Edelman, WR, NE: Knee — Questionable
Impact: Likely just a “smoke and mirrors” designation. Cam Newton may return to the huddle this week to throw passes Edelman’s way.
Sony Michel, RB, NE: Illness/COVID — OUT
Impact: Michel (already on IR) has now been placed on the reserve/COVID-19 list. Rex Burkhead/James White/Damien Harris to split the RB load.
Darius Slayton, WR, NYG: Foot — Questionable
Impact: Expected to play. Quite frankly, there’s nothing behind him on the Giants’ WR depth chart.
DeSean Jackson, WR, PHI: Hamstring — OUT
Impact: Travis Fulgham has the opportunity to attempt an encore of last week’s strong showing.
Alshon Jeffery, WR, PHI: Foot — OUT
Impact: John Hightower/Greg Ward should both see some looks.
Diontae Johnson, WR, PIT: Back — OUT
Impact: Week 5 fantasy darling Chase Claypool will get a chance to prove that it wasn’t a fluke.
Takkarist McKinley, DE, ATL: Groin — OUT
Derek Wolfe, DE, BAL: Neck — Doubtful
Brandon Williams, DT, BAL: Illness/COVID — OUT
Marcus Peters, CB, BAL: Thigh — Questionable
Zach Kerr, DT, CAR: Toe — Questionable
Donte Jackson, CB, CAR: Toe — Questionable
Mackensie Alexander, CB, CIN: Ribs — Questionable
Olivier Vernon, DE, CLE: Groin — Questionable
Larry Ogunjobi, DT, CLE: Abdomen — Questionable
Karl Joseph, S, CLE: Hamstring — OUT
Jeremiah Attaochu, DE, DEN: Quad — OUT
Mike Purcell, DT, DEN: Knee — Questionable
Justin Houston, DE, IND: Hip — Questionable
Denico Autry, DT, IND: Ankle — Questionable
Darius Leonard, LB, IND: Groin — Doubtful
Abry Jones, DT, JAX: Ankle — Questionable
Josh Allen, DE, JAX: Knee — Questionable
Adam Butler, DT, NE: Shoulder — Questionable
Dexter Lawrence, DT, NYG: Knee — Questionable
Lorenzo Carter, LB, NYG: Achilles — OUT
Duke Riley, LB, PHI: Ribs — OUT
Avonte Maddox, CB, PHI: Ankle — OUT
Marcus Epps, S, PHI: Ribs — OUT
Darius Slay, CB, PHI: Concussion — Questionable
DaQuan Jones, DT, TEN: Foot — Questionable
4 p.m. ET games
Sam Darnold, QB, NYJ: Shoulder — Doubtful
Impact: Darnold won’t play. Joe Flacco will start again for the Jets. He should not start for you.
Breshad Perriman, WR, NYJ: Ankle — Questionable
Impact: Even with bye weeks in full swing, look elsewhere for fantasy WR options.
Leonard Fournette, RB, TB: Ankle — Questionable
Impact: It’s all Ronald Jones II in the Buccaneers backfield. Wide receivers Chris Godwin and Mike Evans have both left the injury report and should start.
Za’Darius Smith, LB, GB: Ankle — Questionable
Rashan Gary, LB, GB: Ankle — Questionable
Kevin King, CB, GB: Quad — Questionable
Shaq Lawson, DE, MIA: Shoulder — Questionable
Kyle Van Noy, LB, MIA: Groin — Questionable
Quinnen Williams, DE, NYJ: Hamstring — Questionable
Bless Austin, CB, NYJ: Calf — Questionable
Carlton Davis, CB, TB: Abdomen — Questionable
Sunday night game
Los Angeles Rams
Micah Kiser, LB, LAR: Groin — Questionable
San Francisco 49ers
Kwon Alexander, LB, SF: Ankle — OUT
Emmanuel Moseley, CB, SF: Concussion — Questionable
Official Sunday inactives should begin coming in at approximately 11:30 a.m. ET for the early games and 2:30 p.m. ET for the late games.